Adaptation to the changes in energy metabolism through aging as a strategy of longevity icon

Adaptation to the changes in energy metabolism through aging as a strategy of longevity



НазваниеAdaptation to the changes in energy metabolism through aging as a strategy of longevity
Дата конвертации28.09.2012
Размер445 b.
ТипДокументы


ADAPTATION TO THE CHANGES IN ENERGY METABOLISM THROUGH AGING AS A STRATEGY OF LONGEVITY

  • H.V.TERESHINA T.M. YURINA Russian Research Institute of Gerontology, Moscow




Levels of energy utilization

  • BASAL LEVEL

  • Growth

  • Self maintenance

  • Physical and mental activity

  • Reproduction

  • Thermogenesis

  • EXTREME LEVEL (STRESS)

  • Danger

  • Cold

  • Starvation

  • Immobilization

  • Heat

  • Overnutrition



^ TYPES OF HOMEOSTASIS



SUBSTRATE PREFERENCE











Fatty acids: main functions

  • Fuel

  • Fat deposition (palmitic acid, oleic acid)

  • Membrane structure

  • Phospholipid composition

  • Cholesterol content

  • Raft’s composition

  • Fluidity

  • Receptors’ activity

  • Transmembrane messengers

  • Cholesterol transport and distribution (oleic acid)

  • Immune system

  • Linoleic and arachidonic acid metabolites

  • Regulation of gene transcription (PUFA)



Fatty acids’ role in the onthogenesis

  • Proliferation of somatic cells (growth and development)

  • Boundaries of the reproductive period

  • Energy accumulation (adaptation)




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  • Changes of the free fatty acid content in the blood of girls and boys (young adults) through the 0-25 yr period of life

  • Weight/Height



Changes of the free fatty acid content in blood in onthogenesis



Fatty acid utilization in onthogenesis

  • I period

        • Proliferation (growth and development)
  • II period

        • Reproduction
        • Deposition in the adipose tissue
  • III period

        • Deposition in nonadipose tissues






  • Deposition of fatty acids in adipose tissue reaches its maximum to the end of the reproductive period

  • Adaptative homeostasis (to the environment) decreases





Means of adaptation to the internal stress

  • Deposition of fatty acids in nonadipose tissues

  • Oxidative stress (fatty acids)

  • Cholesterol deposition

  • Proliferation (IGF-I  glucose)

  • Apoptosis (palmitic acid, glucose)  cell loss



Maintenance of the energy homeostasis in the III period as a strategy of longevity

  • Maintenance of the energy homeostasis in the III period as a strategy of longevity

  • Calorie restriction

  • Apoptosis (loss of the

  • cell mass)

  • Physical and mental

  • activity

  • Mild stress



Adaptation is an ability of a system to keep itself by giving an adequate answer not only to challengers of the environment but to the changes of it’s own inner conditions.

  • Adaptation is an ability of a system to keep itself by giving an adequate answer not only to challengers of the environment but to the changes of it’s own inner conditions.

  • Adaptation is an expression of lust for survival and existence as long as possible








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