The Complexity of Human Aging Mutation of mitochondrial dna icon

The Complexity of Human Aging Mutation of mitochondrial dna



НазваниеThe Complexity of Human Aging Mutation of mitochondrial dna
Дата конвертации11.11.2012
Размер445 b.
ТипДокументы



The Complexity of Human Aging

  • Mutation of mitochondrial DNA

  • Accumulation of lipofuscin in lysosomes

  • Protein crosslinking in extra-cellular matrix

  • Cell senescence and cell loss



Furber’s Network Diagram of Aging



Challenges for a Systems Biology of Aging



Formal Representation of Aging Processes



Qualitative Process Models of Aging



Sample Aging Processes



Visualizing a Process Model of Aging



Visualizing a Process Model of Aging



Linking Model Components to Literature



Altering a Process Model of Aging



Visualizing an Altered Model



Reasoning About Aging Processes



Generating Model Predictions



Examining a Model’s Predictions



Tracing an Explanatory Chain



Visualizing an Explanatory Chain



Visualizing Changes in Model Predictions



Status of the Interactive System



Support for the Aging Research Community



Intellectual Influences



Directions for Future Research

  • improve our encoding of aging events and processes

  • formalize more content from Furber’s network diagram

  • add other inference abilities (e.g., therapeutic reasoning)

  • make the system accessible remotely using the Web

  • support community-based development of models

  • evaluate the software’s actual usability for biologists


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Key Contributions

  • encodes aging entities, events, and processes in logical form;

  • displays the resulting models in a graphical notation;

  • draw inferences from a model’s rules and assumptions;

  • identifies the explanatory chains that lead to each result;

  • supports the incremental revision of model components;

  • presents the effects of model revisions on predictions.



End of Presentation





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