Modelling of the individual structural template of protein on determining it nucleotide sequences V. V. Sokolik si «Institute of neurology, psychiatry and narcology of the amsu» icon

Modelling of the individual structural template of protein on determining it nucleotide sequences V. V. Sokolik si «Institute of neurology, psychiatry and narcology of the amsu»



НазваниеModelling of the individual structural template of protein on determining it nucleotide sequences V. V. Sokolik si «Institute of neurology, psychiatry and narcology of the amsu»
Дата конвертации09.07.2012
Размер6.03 Kb.
ТипДокументы


MODELLING OF THE INDIVIDUAL STRUCTURAL TEMPLATE OF PROTEIN ON DETERMINING IT NUCLEOTIDE SEQUENCES

V.V. Sokolik

SI « Institute of neurology, psychiatry and narcology of the AMSU», Kharkov, Ukraine

e-mail: sokolik67@rambler.ru


Key words: a configuration of peptide bond, genetic code of spatial structure of protein, personal structural templates of major actin and ?-actin 1


Motivation and Aim: The novel way of modeling of spatial structure of protein on determining it nucleotide sequences is elaborated. On analogies with rotamers on C—C ?-bound a concept configurations of peptide bound (CPB) is entered as basic element three-dimensional structure of protein, encoded in a genome along with amino acid.

Methods and Algorithms: On ringlateral models of polyalanine it is shown, those three discrete variant configurations of peptide bound (R, 0 and L) determine three different second structures of polypeptide chain: the right spiral, the ?-strand and the left spiral. On the basis of the empirical table of a composite genetic [1] code the author of the given research had been made the ^ table of a genetic code of three-dimensional structure of protein. The important advantage of a method is that it is possible to construct a structural pattern individually for any unknown protein only "having read through" determining it nucleotide sequence in according with the table of a genetic code of spatial structure of protein, and also to decode presence and position of fragments of secondary structure of it.

Results: In this worker were modeled a structural templates of two homologues major actin and ?-actin 1. Its visualized is possible in the graphic editor Ggenedit.exe.

Conclusion: Thus, two homologous proteins (the major actin and ?-actin 1) the identical size (375 а.a.) with identity degree amino acid sequences of 91 % are characterized only 35 % of similarity of sequences of a CPB. It means that such homologues possess various three-dimensional structures and about any general template for its modeling of speech cannot go.

References:

  1. Kushelev A.U., Polischuk S.E., Nedel'ko E.V. (2002) Construction of scale model of structure of protein. Issues of the day of modern science, 2: 236—240.





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